Journal: MedChemComm
Article Title: Antifungal amphiphilic kanamycins: new life for an old drug
doi: 10.1039/c8md00155c
Figure Lengend Snippet: Minimal inhibitory concentrations (MICs) of FG08 and kanamycin B a
Article Snippet: The re-purposing strategy is applicable to other marketed antimicrobial therapeutics that have declined in utility due to the evolution of antimicrobial resistance. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 caption a8 Structure of natural aminoglycosides reported for antifungal activity. table ft1 table-wrap mode="anchored" t5 caption a7 Organism Strain FG08 Kanamycin B Bacteria Escherichia coli TG1 125–250 1.95 Staphylococcus aureus ATC 25923 250 <0.98 Pseudomonas aeruginosa (ATCC 27853) 250 1.95 Enterococcus faecalis (ATCC 29212) 125–250 <0.98 Klebsiella pneumoniae (ATCC 138883) 250 1.95 Klebsiella pneumomiae (ATCC 700603) 250 1.95 Fungi Rhodotorula pilimanae 7.8 >250 Candida albicans 31.3 >250 Saccharomyces cerevisiae W303 31.3 >250 Fusarium graminearum 7.8 >250 Fusarium oxysporum 7.8 >250 Ulocladium spp.
Techniques: